Rwanda: How a New Biannual Anti-HIV Drug Could Benefit Rwanda
A New HIV Preexposure prophylaxis drug, which if approved, will be taken only twice a year and give 100 percent protection to the users, is a good step forward in the fight against the disease, Deo Mutambuka, the Executive Secretary of the Rwanda Networks of people Living with HIV/AIDS (RRP ), has said.
A large clinical trial in South Africa and Uganda has shown that the twice-yearly injection of the new drug - lenacapavir, gives young women total protection from HIV infection, working much better than the currently available options.
Pre-exposure prophylaxis for HIV prevention, commonly known as PrEP, is a form of medication used to prevent HIV infection. PrEP is a general term for the use of medications to prevent the spread of the disease in people who have not yet been exposed to a disease-causing agent. Lenacapavir is a fusion capsid inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV's genetic material and enzymes needed for replication.
The clinical trials for the efficacy of the drug involved 5,000 people who participated at three sites in Uganda and 25 sites in South Africa. The trials aimed at finding out whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill that has been available for more than a decade.
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